Helicopters have been dispatched after five people were injured, two seriously after a two-car crash at the intersection of Isla Bank-Flints Bush Rd and Lindsay-Calcium Rd, 35km northwest of Invercargill.

A St John spokesperson said two people sustained serious injuries in the crash.

One would be transported by rescue helicopter to Dunedin Hospital and the other would be transported to Southland Hospital.

A further three people suffered moderate injuries and would be taken by road ambulance to Southland Hospital.

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